Best Medicine is back in Port Wenn with a pharmacy robbery, a medical mystery and more small-town chaos in Season 2 Episode 2, “Breakin’ In Is Hard to Do.” Josh Charles returns as Dr. Martin Best alongside Abigail Spencer as Louisa Gavin, Eliza Coupe as Eden Montgomery, Stephen Spinella as Greg Garrison and Jason Veasey as George Brady.
When the Port Wenn pharmacy is robbed, Louisa’s critical, time-sensitive medicine is among the items taken. Martin quickly realizes the person responsible may be in need of help themselves, turning the theft into a case that calls on both his sharp diagnostic instincts and his complicated relationship with the town.
Elsewhere, Greg and George go head-to-head with a rival food truck owner, Sarah tries to connect with Eden, and Martin finds himself on the receiving end of Port Wenn’s very particular kind of affection. The new photos offer a first look at the next chapter of the FOX comedy-drama.
Best Medicine Season 2 Episode 2 Promo
When Does Best Medicine Season 2 Episode 2 Air?
Best Medicine Season 2 Episode 2, “Breakin’ In Is Hard to Do,” airs Tuesday, September 29, 2026, from 8:00–9:00 p.m. ET/PT on FOX. Episodes are also available to stream through FOX One.
Thomas Miller is the founder and Editor-in-Chief of Seat42F, covering television, movies and streaming entertainment. He launched Seat42F in 2007 and has spent nearly two decades covering the entertainment industry.
