Best Medicine

Best Medicine is a FOX comedy-drama starring Josh Charles as Martin Best, a brilliant but blunt surgeon who leaves his career in Boston to become the general practitioner in the small seaside community of Port Wenn, Maine. The series follows Martin as he adjusts to small-town life, an eccentric group of residents and relationships that prove considerably more complicated than medicine.

Follow Seat42F’s Best Medicine coverage for the latest series news, episode photos, recaps, reviews, previews, trailers, casting announcements and season updates.

BEST MEDICINE Season 2 Episode 3 : L-R: Josh Charles and Abigail Spencer in the “Crate Expectations” episode of BEST MEDICINE airing Tuesday, October 6 (8:00-9:00 PM ET/PT) on FOX. © 2026 Fox Media LLC. CR: Francisco Roman/FOX.
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Best Medicine Season 2 Episode 3 Photos + Promo: “Crate Expectations”

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Thomas Miller

Best Medicine Season 2 Episode 3 photos and promo preview “Crate Expectations,” airing Tuesday, October 6, at 8:00 p.m. ET/PT ...

Best Medicine Season 2 Episode 2 Breeakin In Is Hard To Do
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Best Medicine Season 2 Episode 2 Photos + Promo: “Breakin’ In Is Hard to Do”

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Thomas Miller

Best Medicine is back in Port Wenn with a pharmacy robbery, a medical mystery and more small-town chaos in Season ...

TV Reviews

Best Medicine Season 2 Episode 1 Recap: Martin’s Secret Is Finally Out

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Thomas Miller

Best Medicine returns to Port Wenn with a premiere that understands exactly what makes the show work: a medical problem ...

BEST MEDICINE: L-R: Abigail Spencer and Josh Charles in the season two premiere of "Be Careful What You Fish For" on Tuesday, September 22 (8:00-9:00 PM ET/PT) on FOX. © 2026 Fox Media LLC. CR: Danielle Mathias/FOX.
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Best Medicine Season 2 Episode 1 Photos: “Be Careful What You Fish For”

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Thomas Miller

Best Medicine is back in Port Wenn — and FOX is giving viewers an early look at Season 2 following ...

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FOX Reveals Its Complete Fall 2026 Premiere Schedule

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Thomas Miller

FOX kicks off the 2026-27 season, announcing premiere dates for a standout fall lineup of returning scripted, unscripted and animated series.  Coming off a banner year, FOX is up +25% ...

Best Medicine season 1 episode 1 : Josh Charles iin the special advance series premiere on Sunday, Jan. 4 (8:00-9:00 PM ET / Live to All Time Zones) immediately following the FOX NFL doubleheader. BEST MEDICINE will have its time period premiere on Tuesday, Jan 6 (8:00-9:00 PM ET/PT) on FOX. © 2026 Fox Media LLC. CR: Francisco Roman/FOX.
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Best Medicine Season 1 Episode 1 Photos Tease Small-Town Chaos

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Thomas Miller

New photos from Best Medicine season 1 episode 1, titled “Docked,” introduce viewers to a charmingly complicated new dramedy as brilliant but brusque ...