Eliza Coupe

BEST MEDICINE: L-R: Abigail Spencer and Josh Charles in the season two premiere of "Be Careful What You Fish For" on Tuesday, September 22 (8:00-9:00 PM ET/PT) on FOX. © 2026 Fox Media LLC. CR: Danielle Mathias/FOX.
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Best Medicine Season 2 Episode 1 Photos: “Be Careful What You Fish For”

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Thomas Miller

Best Medicine is back in Port Wenn — and FOX is giving viewers an early look at Season 2 following ...