THE BIG BANG THEORY is a comedy about brilliant physicists Leonard (Johnny Galecki, second from left) and Sheldon (Jim Parsons, second from right), who are the kind of “beautiful minds” that understand how the universe works, but none of that genius helps them interact with people, especially women. All this begins to change when a free-spirited beauty named Penny (Kaley Cuoco, pictured middle) moves in next door. Sheldon, Leonard’s roommate, is quite content spending his nights playing Klingon Boggle with their socially dysfunctional friends, fellow Cal Tech scientists Wolowitz (Simon Helberg, pictured far left) and Koothrappali (Kunal Nayyar, pictured far right). However, Leonard sees in Penny a whole new universe of possibilities… including love. THE BIG BANG THEORY premiers on Mon., Sept. 24 (8:30-9:00 PM, ET/PT). Photo: Monty Brinton/CBS ©2007 CBS Broadcasting Inc. All Rights Reserved.