| | Movie | Distributor | Weekend Gross | Total Gross |
| 1 | Iron Man | Paramount | 51,190,629 | 177,825,024 |
| 2 | What Happens In Vegas | FOX | 20,172,474 | 20,172,474 |
| 3 | Speed Racer | Warner Brothers | 18,561,337 | 18,561,337 |
| 4 | Made Of Honor | Sony | 8,116,323 | 26,791,494 |
| 5 | Baby Mama | Universal | 6,225,790 | 40,836,370 |
| 6 | Forgetting Sarah Marshall | Universal | 3,837,240 | 50,781,745 |
| 7 | Harold & Kumar Escape | New Line | 3,106,424 | 30,667,308 |
| 8 | Forbidden Kingdom | Lionsgate | 2,169,323 | 48,530,104 |
| 9 | Nim’s Island | FOX | 1,463,622 | 44,395,857 |
| 10 | Prom Night | Sony | 1,012,986 | 42,785,107 |
WEEKEND BOX OFFICE ESTIMATES FOR MAY 9TH – MAY 11TH, 2008