| | Movie | Distributor | Weekend Gross | Total Gross |
| 1 | Indiana Jones and The Kingdom Of The Crystal Skull | Paramount | 100,137,835 | 127,178,907 |
| 2 | Chronicles Of Narnia Prince Caspian | Buena Vista | 22,794,989 | 90,839,999 |
| 3 | Iron Man | Paramount | 20,447,253 | 252,614,669 |
| 4 | What Happens In Vegas | FOX | 9,116,935 | 54,362,827 |
| 5 | Speed Racer | Warner Brothers | 3,942,756 | 36,152,093 |
| 6 | Baby Mama | Universal | 3,355,690 | 52,163,835 |
| 7 | Made Of Honor | Sony | 3,350,618 | 39,011,917 |
| 8 | Forgetting Sarah Marshall | Universal | 1,770,450 | 58,299,420 |
| 9 | Harold & Kumar Escape | New Line | 927,336 | 35,916,292 |
| 10 | The Visitor | Overture | 724,183 | 4,375,408 |
WEEKEND BOX OFFICE ESTIMATES FOR MAY 23RD – MAY 25TH, 2008