| | Movie | Distributor | Weekend Gross | Total Gross |
| 1 | Horton Hears A Who | Fox | 24,590,596 | 86,010,517 |
| 2 | Tyler Perry's Meet The Browns | Lionsgate | 20,082,809 | 20,082,809 |
| 3 | Shutter | FOX | 10,447,559 | 10,447,559 |
| 4 | Drillbit Taylor | Paramount | 10,309,986 | 10,309,986 |
| 5 | 10,000 BC | Warner Brothers | 8,934,064 | 76,401,302 |
| 6 | Never Back Down | Summit | 4,827,250 | 16,790,361 |
| 7 | College Road Trip | Buena Vista | 4,697,683 | 32,073,003 |
| 8 | The Bank Job | Lionsgate | 4,191,773 | 19,521,672 |
| 9 | Vantage Point | Sony | 3,805,541 | 65,300,784 |
| 10 | Under The Same Moon | Weinstein | 2,769,655 | 3,493,542 |
WEEKEND BOX OFFICE ESTIMATES FOR MARCH 21ST – MARCH 23RD, 2008