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Grey’s Anatomy Season 4 Episode Guide

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Grey’s Anatomy Season 4 Episode Guide

Episode 1 – A Change Is Gonna Come – Original Air Date – 09/27/2007

Download A Change Is Going To Come on iTunes

“A Change is Gonna Come” – Having just returned from her honeymoon with Meredith, Cristina searches for Burke, but he’s nowhere to be found. Meredith, Cristina, Izzie and Alex spend their first day as residents with their own groups of interns – among the interns are George, repeating his intern year after failing his exams, and Lexie Grey, Meredith’s half-sister whom she has never met. Now that Derek’s relationship with Meredith has reached an emotional impasse, he looks to his fellow doctors for friendship; Bailey wrestles with her place within the hospital now that her former interns report to new Chief Resident Callie; and Richard resumes his position as Chief of Surgery, on the season premiere of “Grey’s Anatomy,” THURSDAY, SEPTEMBER 27 (9:00-10:01 p.m., ET) on the ABC Television Network.

Guest Cast: Mark Pellegrino as Chris, Sandra Thigpen as Clara, Stephanie Childers as Nancy, Steven M. Porter as Joey, Candice Afia as Intern Laura, Amrapali Ambegaokar as Intern Dani, Tymberlee Chanel as Intern Claire, Gloria Garayua as Intern Graziella, Molly Kidder as Intern Megan, Richard Keith as Intern Mitch, Joy Osmanski as Intern Lucy, Winston Story as Intern Leo and Joseph Williamson as Intern Pierce.
    
“A Change Is Gonna Come” was written by Shonda Rhimes and directed by Rob Corn.

Episode 2 – Love/Addiction – Original Air Date – 10/04/2007

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“Love/Addiction” – The residents and interns treat the victims of a massive explosion at an apartment building, while Alex investigates the cause of the accident, Mama Burke returns to collect her son’s things just as Cristina trades her wedding presents in exchange for surgeries, Lexie tries to have a heart-to-heart with an unwilling Meredith, and while Callie is overwhelmed with her duties as Chief Resident, Bailey searches for an outlet for her pent-up leadership skills, on “Grey’s Anatomy,” THURSDAY, OCTOBER 4 (9:00-10:01 p.m., ET) on the ABC Television Network.

Guest Cast: Ben Vereen as Archie, Brendan Elliott as Dave, Nicholas Gonzalez as Clark and Diahann Carroll as Jane Burke.

“Love/Addiction” was written by Debora Cahn and directed by James Frawley.

Episode 3 – Let The Truth Sting – Original Air Date – 10/11/2007

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“Let the Truth Sting” – The new interns are dazzled by the skill level of fellow intern George, while Lexie helps keep his “repeater” status a secret; Meredith half-heartedly helps Lexie with her first emergency patient; Sloan and Richard attempt a radical, new surgery to save a woman’s ability to speak; and George is compelled to tell Callie of his past indiscretion with Izzie, on “Grey’s Anatomy,” THURSDAY, OCTOBER 11 (9:00-10:01 p.m., ET) on the ABC Television Network.

Guest Cast: Edward Herrmann as Norman, Caroline Aaron as Connie, Eve Gordon as Mary, Amy Hill as Joanne, Debra Christofferson as Elaine and Jack Axelrod as really old guy.

“Let the Truth Sting” was written by Mark Wilding and directed by Dan Minahan.

Episode 4 – The Heart Of The Matter – Original Air Date – 10/18/2007

“The Heart of the Matter” – The Chief’s wife, Adele, rushes their niece to Seattle Grace, the hospital where she once had her prom, Izzie reveals her feelings for George to a mutual friend, and the reaction is not what she expects, Derek teaches Cristina how to be a better teaching resident, and the world’s oldest living intern, Norman, misdiagnoses one of Meredith’s patients, on “Grey’s Anatomy,” THURSDAY, OCTOBER 18 (9:00-10:02 p.m., ET) on the ABC Television Network.

Guest Cast: Edward Herrmann as Norman, Michael McGrady as Stanley, Matt Lanter as Adam, Maggie Siff as Ruthie, Miriam Flynn as Ms. Bitzer, Camille Winbush as Camille, Ron Melendez as Will, with Loretta Devine as Adele.

“The Heart of the Matter” was written by Allan Heinberg and directed by Randy Zisk.

Episode 5 – Haunt You Every Day – Original Air Date – 10/25/2007

“Haunt You Every Day” – It’s Halloween, and the day is full of surprises for the doctors of Seattle Grace – Alex receives an unexpected and welcome visit from his former patient, Ava/Rebecca, Meredith is convinced that her mother’s ashes are haunting her, Cristina is snubbed by a surgeon she admires, and Callie announces George and Izzie’s affair to their fellow doctors, on “Grey’s Anatomy,” THURSDAY, OCTOBER 25 (9:00-10:02 p.m., ET) on the ABC Television Network.

Guest Cast: Edward Herrmann as Norman, Elizabeth Reaser as Ava, Rocky Carroll as James, Kali Rocha as Sydney, David Clennon as Jack, Dylan Minnette as Ryan, Sarah Utterback as Olivia and Anjul Nigam as Raj.

“Haunt You Every Day” was written by Krista Vernoff and directed by Bethany Rooney.

Episode 6 – Kung Fu Fighting – Original Air Date – 11/01/2007

“Kung Fu Fighting” – With his marriage in turmoil, the Chief turns to his fellow male surgeons for a “gentleman’s evening,” Cristina and Izzie heatedly compete for the same surgeries and the favor of the doctor performing them, Meredith treats the survivor of a skydiving accident, and the doctors treat two injured finalists who are competing in a promotional competition, on “Grey’s Anatomy,” THURSDAY, NOVEMBER 1 (9:00-10:07 p.m., ET) on the ABC Television Network.

Guest Cast: David Denman as Rick, Cullen Douglas as Mr. Arnold, Marina Black as Sally, Tommy Dewey as Mike, Amanda Loncar as  Jackie, Steve Sandvoss as Jason and Chryssie Whitehead as Helena.

“Kung Fu Fighting” was written by Stacy McKee and directed by Tom Verica.

Episode 7 – Physical Attraction…Chemical Reaction – Original Air Date – 11/08/2007

“Physical Attraction… Chemical Reaction” – George and Izzie’s romantic chemistry is put to the test, as Derek asks for more than a physical connection from Meredith; much to his own surprise, Mark develops a crush on a fellow surgeon, and Callie’s role as Chief Resident is placed in jeopardy after she delegates much of her job to Bailey, on “Grey’s Anatomy,” THURSDAY, NOVEMBER 8 (9:00-10:02 p.m., ET) on the ABC Television Network.

Guest Cast: Jeff Perry as Thatcher, Rockmond Dunbar as Sean, Stephanie March as Jane, Vicki Lewis as Harriet, David Burke as Don, Kurt Fuller as  Jerry and Enuka Okuma as Teresa.

“Physical Attraction… Chemical Reaction” was written by Tony Phelan and Joan Rater and directed by Jeff Melman.

Grey's Anatomy Episode Guide Photo 

Episode 8 – Forever Young – Original Air Date – 11/15/2007

“Forever Young” – The ER is filled with teenagers after a schoolbus crash, Bailey treats a patient who was her high school crush, Derek goes out on a date with a fellow doctor, and Thatcher enters the ER looking for Meredith, on “Grey’s Anatomy,” THURSDAY, NOVEMBER 15 (9:00-10:02 p.m., ET) on the ABC Television Network.

Guest Starring Jeff Perry as Thatcher, Kali Rocha as Sydney, D.B. Woodside as Marcus, Lauren Stamile as Rose, Madeline Zima as Marissa, Brooke Nevin as Tricia and Stephen Sowan as Danny.

“Forever Young” was written by Mark Wilding and directed by Rob Corn.

Grey's Anatomy Episode Guide Photo

Episode 9 – Crash Into Me Part One – Original Air Date – 11/22/2007

“Crash Into Me — Part One” – An ambulance crash endangers the lives of the paramedics involved, as Meredith and the Chief work on-site to save them, Bailey treats a patient who refuses her help, and Ava returns for Alex and meets his other girlfriend in the process, on “Grey’s Anatomy,” THURSDAY, NOVEMBER 22 (9:00-10:02 p.m., ET) on the ABC Television Network.

Guest Starring Meggan Anderson (Nurse), Emma Prescott (Lucy Nolston), Elizabeth Reaser (Rebbeca Pope), Seth Green (Nick), Gale Harold (Shane), Cress Williams (Tucker Jones), Lauren Stamile (Rose), John Billingsley (Jacob Nolston), Theo Rossi (Stan Giamatti), Kimberly Huie (Mary Daltrey), Alison Laplaca (Mrs. Nolston)

“Crash Into Me Part One” was written by Krista Vernoff and Shonda Rhimes and directed by Michael Grossman.

Grey's Anatomy Episode Guide Photo 

Episode 10 – Crash Into Me Part Two – Original Air Date – 12/06/2007

“Crash Into Me, — Part Two” – In the stunning conclusion of a two-part episode, Meredith furiously works to save the life of a paramedic trapped inside an ambulance, as her sister, Lexie, holds the life of a patient in her hands; Derek must rely on the help of a nurse to save a patient’s life, as Bailey struggles to balance her personal life with her work, on “Grey’s Anatomy,” THURSDAY, DECEMBER 6 (9:00-10:02 p.m., ET) on the ABC Television Network.

Guest starring Emma Prescott (Lucy Nolston), Seth Green (Nick), Elizabeth Reaser (Rebecca Pope), Cress Williams (Tucker Jones), Lauren Stamile (Rose), Gale Harold (Shane), Kimberly Huie (Mary), Theo Rossi (Stan), Alison Laplaca (Jacob’s Wife), John Billingsley (Jacob)

“Crash Into Me Part Two” was written by Shonda Rhimes and Krista Vernoff and directed by Jessica Yu.

Episode 11 – Lay Your Hands On Me – Original Air Date – 01/10/2008

“Lay Your Hands on Me” – Bailey’s family faces a medical trauma, just as her marriage is falling apart; a surprise visit from George’s mother comes as a shock to both Izzie and Callie; a faith healer challenges Erica and Alex’s beliefs in traditional medicine; and Derek must deal with the aftermath of his kiss with Rose, on “Grey’s Anatomy,” THURSDAY, JANUARY 3 (9:00-10:02 p.m., ET) on the ABC Television Network.

Guest starring Glenne Headly as Elizabeth, Debra Monk as Louise O’Malley, Cress Williams as Tucker, Lauren Stamile as Rose and Carol Locatell as Mai.

“Lay Your Hands on Me” was written by Allan Heinberg and directed by John Terlesky.

Episode 12 – Where The Wild Things Are- Original Air Date – 04/24/2008

“Where the Wild Things Are” – Six weeks after Derek and Meredith ended their relationship and Derek began dating Rose, Meredith and her fellow residents, Alex, Izzie and Cristina, compete in a surgical contest, with Bailey serving as judge. Meanwhile interns George and Lexie adjust to their new, squalid apartment, and Callie finds a friend in her roommate Cristina’s nemesis, Erica Hahn, on “Grey’s Anatomy,” THURSDAY, APRIL 24 (9:00-10:01 p.m., ET) on the ABC Television Network.

Guest starring Amy Madigan as Dr. Wyatt, Cheech Marin as Otis, Clea Duvall as Jennifer, Lauren Stamile as Rose, Steven Flynn as Scott with Jason O’Mara as Phillip. Co-starring Troy Westbrook as paramedic.

“Where the Wild Things Are” was written by Zoanne Clack and directed by Rob Corn.

Episode 13 – Piece Of My Heart – Original Air Date – 05/01/2008 

“Piece of My Heart” – Addison returns to Seattle Grace to perform an operation and is taken aback by all of the changes in her old co-workers’ lives. Meanwhile Meredith and Derek’s clinical trial has its first patient, and Rebecca/Ava returns with shocking news for Alex, on “Grey’s Anatomy,” THURSDAY, MAY 1 (9:00-10:01 p.m., ET) on the ABC Television Network.

Guest starring are Kate Walsh as Addison, Amy Madigan as Dr. Wyatt, Elizabeth Reaser as Rebecca, Clea Duvall as Jennifer, Lauren Stamile as Rose, Kathleen Rose Perkins as Sarah, Ken Barnett as Freddie, with Jason O’Mara as Phillip.  

“Piece of My Heart” was written by Stacy McKee and directed by Mark Tinker.

Episode 14 – The Becoming – Original Air Date – 05/08/2008

“The Becoming” – The nurses’ objections to McSteamy’s trysts lead to the instating of a new “date and tell” policy. Meanwhile news of Burke’s latest career achievements force Cristina to face her feelings for her ex, Meredith and Derek admit a veteran soldier into their clinical trial, and Callie turns to Sloan in her time of need, on “Grey’s Anatomy,” THURSDAY, MAY 8 (9:00-10:02 p.m., ET) on the ABC Television Network.

“Grey’s Anatomy” stars Ellen Pompeo as Meredith Grey, Patrick Dempsey as Derek Shepherd, Sandra Oh as Cristina Yang, Katherine Heigl as Isobel “Izzie” Stevens, Justin Chambers as Alex Karev, T.R. Knight as George O’Malley, Chandra Wilson as Miranda Bailey, James Pickens, Jr. as Richard Webber, Sara Ramirez as Callie Torres, Eric Dane as Mark Sloan, Chyler Leigh as Lexie Grey and Brooke Smith as Erica Hahn.

Guest starring Amy Madigan as Dr. Wyatt, Lauren Stamile as Rose, John M. Jackson as Kevin, Benny Ciaramello as Darren, Zilah Mendoza as Kyra, David Giuntoli as Todd and Loretta Devine as Adele.

“The Becoming” was written by Tony Phelan and Joan Rater and directed by Julie Ann Robinson.

Episode 15 – Losing My Mind – Original Air Date – 05/15/2008

“Losing My Mind” – Dr. Wyatt refuses to let Meredith give up on therapy, Alex learns the truth about Rebecca’s medical condition, the Chief insists that Erica perform a risky surgery on his mentor, and after receiving news of Burke, Cristina continues to do things contrary to her nature, going so far as cleaning her always-messy apartment, on “Grey’s Anatomy,” THURSDAY, MAY 15 (9:00-10:02 p.m., ET) on the ABC Television Network

Guest cast TBA.

“Losing My Mind” was written by Debora Cahn and directed by Jim Frawley.

Episode 16 – Freedom – Original Air Date – 05/22/2008 

“Freedom” – On the two-hour season finale of “Grey’s Anatomy,” Meredith and Derek have one last shot at a successful outcome in their clinical trial, as the other surgeons work together to free a boy from a hardening block of cement. Meanwhile, Izzie helps Alex care for an ailing Rebecca, and Lexie discovers critical information about George’s intern status, on “Grey’s Anatomy,” THURSDAY, MAY 22 (9:00-11:00 p.m., ET) on the ABC Television Network.

Guest guest TBA.

“Freedom” was written by Shonda Rhimes and directed by Rob Corn.

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