Recipient of the 2007 Golden Globe Award for Best Drama Television Series and multiple Emmy nominations, including Outstanding Drama Series for the past two years, “Grey’s Anatomy” returns to the ABC Television Network for its fourth season.

Entering their first year as residents after passing their intern exams, Meredith Grey, Cristina Yang, Izzie Stevens and Alex Karev now have interns of their own to mentor. Among the new crop of interns are George (forced to repeat his internship after failing his exams) and Lexie Grey, Meredith’s half-sister.

Overseeing the residents is the newly-appointed Chief Resident, Callie Torres. With the no-nonsense Miranda Bailey earning the interns’ respect over the past year, the new residents are finding it difficult to report to someone else, particularly George’s wife.

Bailey, who is displeased with Dr. Webber after he chose Callie for Chief Resident over her, must find her bearings within the hospital pecking order. While she finds her footing, Webber resumes his position as Chief of Surgery, doing his best to maintain a work/life balance for the sake of his recently-reunited marriage.

Two weeks after being left by her fiancé on her wedding day, Cristina returns to the hospital from her honeymoon accompanied by Meredith, who badly needed an escape of her own after her relationship with Derek Shepherd hit an emotional impasse. Cristina relies on what she always has – her ability as a surgeon – to cope with the break-up.

Mark Sloan wishes to renew his friendship with his old friend, Derek, who could sorely use a friend after Addison’s move, Burke’s resignation and his rocky relationship with Meredith.

The doctors of Seattle Grace Hospital deal with life-or-death consequences on a daily basis – it’s in one another that they find comfort, friendship and, at times, more than friendship. Together they’re discovering that neither medicine nor relationships can be defined in black and white. Real life only comes in shades of grey.

“Grey’s Anatomy” stars Ellen Pompeo as Meredith Grey, Patrick Dempsey as Derek Shepherd, Sandra Oh as Cristina Yang, Katherine Heigl as Isobel “Izzie” Stevens, T.R. Knight as George O’Malley, Justin Chambers as Alex Karev, Chandra Wilson as Miranda Bailey, James Pickens, Jr. as Richard Webber, Sara Ramirez as Callie Torres, Eric Dane as Mark Sloan and Chyler Leigh as Lexie Grey.

“Grey’s Anatomy” was created and is executive produced by Shonda Rhimes (“Introducing Dorothy Dandridge”). Betsy Beers (“Casanova”), Mark Gordon (“Saving Private Ryan”), Krista Vernoff (“Law & Order”) and Rob Corn (“Chicago Hope”) are executive producers. “Grey’s Anatomy” is an ABC Studios production.