In addition to attracting a fanatically loyal viewing audience, MONK has been a virtual launch pad for guest star Emmys, with four nominations and two wins over the past three seasons. In the 100th episode, aptly named "Mr. Monk's 100th Case," a magazine news show, "In Focus," covers Adrian Monk's handling of a serial killer case where four people are murdered. When the gang, including Stottlemeyer, Disher and Natalie gathers for a viewing party to watch the serial killer segment, Monk sees the interviews of his closest friends and adversaries and realizes that something about the case leaves him unsettled.
Guest-starring in the episode are Eric McCormack ("Will & Grace," "The Andromeda Strain") as "In Focus" reporter James Curry and Kathryn Joosten ("Desperate Housewives," "The West Wing") as Monk's former babysitter. Returning in their recurring – and memorable – roles are John Turturro (who won an Emmy for his role) as Monk's agoraphobic brother, Ambrose; Jarrad Paul as Monk's neighbor Kevin Dorfman; and Tim Bagley as Monk's nemesis Harold Krenshaw. Some of Monk's favorite criminals returning from behind bars are Sharon Lawrence as Stottlemeyer's killer ex-girlfriend Linda Fusco; Andy Richter as Hal Tucker; David Koechner as Joey Krenshaw; Ricardo Chavira as Jimmy Belmont; and Angela Kinsey as Arlene Boras. Also appearing in the episode are returning guest-stars Howie Mandel as former cult leader Ralph Roberts; Sarah Silverman as Monk's biggest fan Marci Maven; and Brooke Adams as Leigh Harrison, a flight attendant Monk encountered on his travels.